Effect of Cordyceps sinensis on TIMP-1 secretion from mouse melanoma cell

摘要: Cordyceps sinensis is a Chinese medicinal fungus traditionally used in cancer treatments. In previous study, we investigated the antimetastatic activity of (WECS) extract using liver metastatic model mice injected with B16-F0 mouse melanoma cells into spleen. WECS reduced number nodules C57BL/6 mice, and significantly prolonged survival mice. Furthermore, examined effects on hepatocyte growth factor (HGF)-accelerated invasion chemo-invasion assay vitro. was shown to reduce HGF-accelerated cell invasion. present effect Tissue Inhibitor Metalloproteinase (TIMP)-1 secretion from order identify clues mechanism underlying anti-invasive action WECS. As result, increased TIMP-1 cells. Moreover, cordycepin (3′-deoxyadenosine), component WECS, potentially pharmacologically active ingredient extract. Cordycepin accelerate release These findings suggest that exerts activity, part by increasing cells, functions as effective component.