Evaluation of basilar artery and cerebrospinal fluid dynamics using phase‐contrast MRI: Comparison between mannitol and isotonic saline solution

摘要: Increased intracranial pressure (ICP) can cause irreversible pathological changes in the canine brain and be life-threatening, so prompt diagnosis therapeutic responses are warranted. The purposes of this prospective experimental study were to evaluate phase-contrast MRI (PC-MRI) as a non-invasive method for quantifying cerebrospinal fluid (CSF) basilar artery flow, assess effects intravenous administration hypertonic fluid. A PC-MRI scan was acquired six healthy Beagle dogs at level mesencephalic aqueduct. Either 1.0 g/kg mannitol or isotonic saline solution administered intravenously 15 min each matched dose volume 5 mL/kg. Basilar CSF flow rates measured their values compared between groups before administration, subsequently every 2 h post-administration. dynamics further assessed by measuring repeat from caudal rostral direction number waves. No significant difference observed velocity two (P > .05). However, tended increase slightly over time, while remained unchanged. In group, wave forms reduced 60 75 Findings preliminary indicated that it is feasible measure PC-MRI, but no differences could detected versus administration.