Neuroinflammation in spinal cord injury: therapeutic targets for neuroprotection and regeneration.
作者： Jessica K. Alexander , Phillip G. Popovich
DOI: 10.1016/S0079-6123(09)17508-8
关键词:
摘要: Traumatic spinal cord injury triggers a complex local inflammatory reaction capable of enhancing repair and exacerbating pathology. The composition effector potential the post-injury cellular molecular immune cascade changes as function time distance from lesion. Production along this time-space continuum cytokines, proteases, growth factors establishes dynamic environments that lead to death, damage, or affected neurons glia. Microenvironmental cues, therefore, generated by cells therein, may determine these distinct fates versus To harness repair, it is necessary manipulate assembly phenotype comprise neuroinflammatory response injury. Here, cause outcomes such pain, regeneration, functional recovery reviewed.
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