Development of a new family of monolithic calcium (pyro)phosphate glasses by soft chemistry

摘要: The development of bioactive phosphate-based glasses is essential in biomaterials science, and especially for bone substitution applications. In this context, the preparation amorphous calcium-phosphorus hydroxide/oxide monoliths at low temperature a key challenge being able to develop novel hybrid materials these We herein report first time synthesis physical chemical characterisation family pyrophosphate-based (with formula: {[(Ca2+)1−x(H+/K+)2x]2[(P2O74−)1−y(PO43−)4y/3]} n(H2O)), which were prepared by soft chemistry using temperatures (T < 70 °C) water as solvent. effect initial Ca/Pyrophosphate ratio on structure morphology pyrophosphate was investigated detail. Depending ratio, glass (mixed calcium pyro- orthophosphate) or glass-ceramic (Ca10K4(P2O7)6·9H2O crystals embedded phase) obtained. proportion crystalline phase increased with an increase batch solution. As expected glass, formation glassy material demonstrated not be thermodynamically but rather kinetically driven, washing step found crucial prevent crystallisation. stability discussed considering structural degrees freedom entities, ionic strength solution inhibitory orthophosphate ions. Overall, new strategy monolithic calcium-(pyro)phosphate based highly promising view preparing functional organic-inorganic hybrids