CELLULAR LOCALIZATION OF P-GLYCOPROTEIN IN BRAIN VERSUS GONADAL CAPILLARIES

摘要: P-glycoprotein, the multidrug resistance protein that actively transports a wide variety of lipophilic substrates out cancer cells, has recently been described in some normal tissues, including endothelium brain and testes. Here we show P-glycoprotein is also expressed ovarian endothelium. In capillaries, immunolabeled was detected with two monoclonal antibodies to P-glycoprotein. It shown be membrane-bound transport known substrate. Expression endothelial cells suggests this plays role enhancing or restricting vascular permeability molecules. If it does, then its may predicted from site expression on luminal abluminal face capillary wall. region nucleus, membranes are sufficiently far apart they can distinguished at light microscopic level. Confocal examination tissue sections double labeled for nuclei confirmed that, brain, only membranes. This location consistent putative protecting neuropil circulating both testicular endothelium, however, localization acts exclude themselves.