Simulations of submicron aerosol deposition at an air–liquid interface for in vitro toxicology

摘要: Submicron particles released during the lifecycle of nano-enabled products and as a byproduct air pollution occupational processes are potential health risk. Recent advancements to in vitro model systems have been proposed assess toxicity particulate materials resulting from inhalation. The reliability these models depends on introduction deposition aerosolized cells at an air–liquid interface. However, chamber geometry, gas flow rate, electric field, other process parameters significantly impact how deposit this Here, we carried out finite element modeling describe transport submicron particles. Simulations were performed using multiphysics software typical exposure design, results compared analytical approximations for efficiency. Deposition experiments also systematically validate predictions. Our show various parameters. To achieve efficient without focusing, field strength rate must be balanced; high rates, higher fields required deposition. Further, find that AC appropriate frequency can increase above DC similar strengths. Overall, study establishes simulation approaches design aerosol chambers relates key deposition, which is critical controlling dose aerosols toxicology experiments.