Toxicity of Pb‐contaminated soil to Japanese quail (Coturnix japonica) and the use of the blood–dietary Pb slope in risk assessment

摘要: This study relates tissue concentrations and toxic effects of Pb in Japanese quail (Coturnix japonica) to the dietary exposure soil-borne associated with mining smelting. From 0% 12% contaminated soil, by weight, was added 5 experimental diets (0.12 382 mg Pb/kg, dry wt) fed for 6 weeks. Benchmark doses a 50% reduction delta-aminolevulinic acid dehydratase activity were 0.62 mg Pb/kg blood, wt, 27 mg diet. 20% increase concentration erythrocyte protoporphyrin 2.7 mg blood 152 mg The showed no other signs toxicity (histopathological lesions, alterations plasma–testosterone concentration, body organ weights). relation soil linear, slope 0.013 mg (dry divided mg We suggest that this is potentially useful ecological risk assessments on birds same way intake factor an important parameter children exposed Pb. may also be used tissue-residue approach as additional line evidence assessment, supplementary estimate hazard based reference values. Integr Environ Assess Manag 2014;10:22–29. © 2013 SETAC