Genetics of Osteoporosis - Studies on bone size, structure and strength in the rat

摘要: Osteoporosis is characterized by decreased bone mineral density (BMD) leading to reduced strength and increased fracture risk. Several heritable components affect a bone’s ability resist fracture, including size, structure strength; therefore identification of the genes underlying several characteristics will help elucidate pathogenesis Dissection genetic determinants osteoporosis has been more effective in animal models than human populations due possibility environmental control minimization heterogeneity. The aim this thesis was identify quantitative trait loci (QTLs) affecting osteoporosis-related phenotypes an F2 intercross between diabetic GK non-diabetic F344 rats, differing their mitochondrial (mt) DNA. For measurements, tibia were using four different methods generating skeletal Comprehensive analysis identified chromosomal regions linked that influenced both sex- reciprocal cross. A region on chromosome 1 with linkage also fasting glucose, making as strong candidate for localisation contributing regulation potentially type-2 diabetes. observed interaction nuclear QTLs cross, demonstrates new interesting aspect when interpreting genetics related strength. Furthermore, preliminary studies suggest rat model can be useful tool delineate diabetes conjunction lifestyle factors such high-fat diet. (Less)