Filaria-Induced Immune Evasion: Suppression by the Infective Stage ofBrugia malayiat the Earliest Host-Parasite Interface
作者： Roshanak Tolouei Semnani , Melissa Law , Joseph Kubofcik , Thomas B. Nutman
DOI: 10.4049/JIMMUNOL.172.10.6229
关键词:
摘要: To assess the physiologic interactions between infective stage of Brugia malayi —one extracellular parasites responsible for lymphatic filariasis in humans—and APC with which they come contact during their development and routes travel, we have investigated interaction (L3) B. human Langerhans cells (LC) skin. Our data indicate that live L3 result increased migration LC from epidermis without affecting viability these up-regulation IL-18 cytokine involved migration. Live also down-regulation MHC class I II on cell surface. Additionally, microarray significantly down-regulated expression IL-8 as well multiple genes Ag presentation, reducing capacity to induce CD4 + T allogeneic MLR, thus resulting a decreased ability promote proliferation production IFN-γ IL-10. These suggest exert down-regulatory response epidermal leads diminished activate cells.
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