Enantioselective addition of diethylzinc to aldehydes catalyzed by pyridineoxazolinealcohols
作者： Emmanuel Macedo , Christina Moberg
DOI: 10.1016/0957-4166(95)00039-R
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摘要: Abstract Chiral 2-pyridylcarbinols carrying chiral oxazolyl substituents in the 6-position of pyridine ring catalyze enantioselective addition diethylzinc to aromatic aldehydes. The absolute configuration product alcohol is determined by at stereogenic center bearing group, effect oxazoline being increase stereoselectivity. Attempts use methyl ether derivatives same ligands rhodium-catalyzed hydrosilylation acetophenone did not result any observed enantioselectivity.
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