Immune reactivity to expressed activated oncogenes for diagnosis of malignancy

作者: David J. Peace , Martin A. Cheever

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摘要: Methods for the detection, monitoring and treatment of malignancies are disclosed. Detection proliferation T cells in response to vitro exposure a protein expression product an activated oncogene or cancer-related gene associated with malignancy, detection immunocomplexes formed between antibodies body fluid, allows diagnosis presence malignancy. The present invention also discloses methods compositions treating

参考文章(36)
Juan C. Lacal, Stuart A . Aaronson, Deletion mutants and monoclonal antibodies against ras proteins ,(1986)
J.P. Brown, P.W. Wright, C.E. Hart, R.G. Woodbury, K.E. Hellström, I. Hellström, Protein antigens of normal and malignant human cells identified by immunoprecipitation with monoclonal antibodies Journal of Biological Chemistry. ,vol. 255, pp. 4980- 4983 ,(1980) , 10.1016/S0021-9258(19)70731-5
Eugenio Santos, Angel R. Nebreda, Structural and functional properties of ras proteins. The FASEB Journal. ,vol. 3, pp. 2151- 2163 ,(1989) , 10.1096/FASEBJ.3.10.2666231
J McLaughlin, E Chianese, O N Witte, Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells. Molecular and Cellular Biology. ,vol. 9, pp. 1866- 1874 ,(1989) , 10.1128/MCB.9.5.1866
Johannes L. Bos, The ras gene family and human carcinogenesis Mutation Research/Reviews in Genetic Toxicology. ,vol. 195, pp. 255- 271 ,(1988) , 10.1016/0165-1110(88)90004-8
Kathleen Forrester, Concepcion Almoguera, Kyuhyung Han, William E. Grizzle, Manuel Perucho, Detection of high incidence of K- ras oncogenes during human colon tumorigenesis Nature. ,vol. 327, pp. 298- 303 ,(1987) , 10.1038/327298A0