Drugs affecting blood coagulation and hemostasis

摘要: Publisher Summary This chapter discusses the drugs that affect blood coagulation and hemostasis in. It describes study in which bleeding risk of low-dose heparin prophylaxis was assessed patients undergoing major surgery for gynecologic malignancy. Controlled trial 182 received either or no antithrombotic medication at all. The low dose heparin-treated had significantly increased daily retroperitoneal hemovac drainage. No significant increase intraoperative loss, transfusion requirements, wound hematomas, lymphocysts observed. In comparison with heparin, addition dihydroergotamine (DHE) did not reduce frequency complications. Similar results were obtained two smaller studies involving only abdominal surgery. Women on long-term anticoagulant treatment because cardiac valvular prostheses congestive heart failure have an complications during pregnancy. A has demonstrated a circadian change effect infused constant rate. measured using activated partial thromboplastin time, thrombin Factor-Xa-inhibition assay. Maximum values achieved night minimum morning.