Recommendations to improve the clinical adoption of NGS-based cancer diagnostics in Singapore.

Bernard Burnand, Steven J. Bernstein, Kathryn Fitch, Marfa D. Aguilar, Juan R. LaCalle, The Rand/UCLA Appropriateness Method User's Manual ,(2001)

Peter P. Cheung, Manjari Lahiri, Gim-Gee Teng, Nai-Lee Lui, Faith L. Chia, Dow-Rhoon Koh, Wei-Howe Koh, Swee-Cheng Ng, Ernest Suresh, Khai-Pang Leong, Anita Y. N. Lim, Julian Thumboo, Tang-Ching Lau, Keng-Hong Leong, Consensus development on eligibility of government subsidisation of biologic disease modifying anti‐rheumatic agents for treatment of ankylosing spondylitis: The Singapore experience International Journal of Rheumatic Diseases. ,vol. 20, pp. 1517- 1526 ,(2017) , 10.1111/1756-185X.12707

PhD Jeffery M. Klco, MD, PhD Christopher A. Miller, PhD Malachi Griffith, PhD Allegra Petti, PhD David H. Spencer, MD, MS Shamika Ketkar-Kulkarni, MD Lukas D. Wartman, PhD Matthew Christopher, MD, BS Tamara L. Lamprecht, BS Nicole M. Helton, MD Eric J. Duncavage, PhD Jacqueline E. Payton, MD, BA Jack Baty, Sharon E. Heath, PhD Obi L. Griffith, PhD Dong Shen, MS Jasreet Hundal, PhD Gue Su Chang, MS Robert Fulton, BS Michelle O'Laughlin, BS Catrina Fronick, PhD Vincent Magrini, BE Ryan T. Demeter, PhD David E. Larson, PhD Shashikant Kulkarni, MS, PhD Bradley A. Ozenberger, PhD John S. Welch, MD, MD Matthew J. Walter, MD Timothy A. Graubert, PhD Peter Westervelt, MD, MD Jerald P. Radich, MD Daniel C. Link, PhD Elaine R. Mardis, PhD John F. DiPersio, MD, PhD Richard K. Wilson, MD Timothy J. Ley, Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia JAMA. ,vol. 314, pp. 811- 822 ,(2015) , 10.1001/JAMA.2015.9643

C.H. Köhne, R. Labianca, T. Price, W. Scheithauer, A. Sobrero, J. Tabernero, D. Aderka, S. Barroso, G. Bodoky, J.Y. Douillard, H. El Ghazaly, J. Gallardo, A. Garin, R. Glynne-Jones, K. Jordan, A. Meshcheryakov, D. Papamichail, P. Pfeiffer, I. Souglakos, S. Turhal, A. Cervantes, H.J. Schmoll, E. Van Cutsem, A. Stein, V. Valentini, B. Glimelius, K. Haustermans, B. Nordlinger, C.J. van de Velde, J. Balmana, J. Regula, I.D. Nagtegaal, R.G. Beets-Tan, D. Arnold, F. Ciardiello, P. Hoff, D. Kerr, ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making Annals of Oncology. ,vol. 23, pp. 2479- 2516 ,(2012) , 10.1093/ANNONC/MDS236

C. Lim, M.S. Tsao, L.W. Le, F.A. Shepherd, R. Feld, R.L. Burkes, G. Liu, S. Kamel-Reid, D. Hwang, J. Tanguay, G. da Cunha Santos, N.B. Leighl, Biomarker testing and time to treatment decision in patients with advanced nonsmall-cell lung cancer Annals of Oncology. ,vol. 26, pp. 1415- 1421 ,(2015) , 10.1093/ANNONC/MDV208

F. Ciardiello, N. Normanno, E. Maiello, E. Martinelli, T. Troiani, S. Pisconti, F. Giuliani, C. Barone, G. Cartenì, A.M. Rachiglio, V. Montesarchio, G. Tonini, D. Rizzi, S. Cinieri, R. Bordonaro, A. Febbraro, F. De Vita, M. Orditura, F. Fenizia, M. Lambiase, A. Rinaldi, F. Tatangelo, G. Botti, G. Colucci, Clinical activity of FOLFIRI plus cetuximab according to extended gene mutation status by next-generation sequencing: findings from the CAPRI-GOIM trial Annals of Oncology. ,vol. 25, pp. 1756- 1761 ,(2014) , 10.1093/ANNONC/MDU230

Luís Felipe Campesato, Romualdo Barroso-Sousa, Leandro Jimenez, Bruna R. Correa, Jorge Sabbaga, Paulo M. Hoff, Luiz F. L. Reis, Pedro Alexandre F. Galante, Anamaria A. Camargo, Comprehensive cancer-gene panels can be used to estimate mutational load and predict clinical benefit to PD-1 blockade in clinical practice Oncotarget. ,vol. 6, pp. 34221- 34227 ,(2015) , 10.18632/ONCOTARGET.5950

Linda M. Sabatini, Charles Mathews, Devon Ptak, Shivang Doshi, Katherine Tynan, Madhuri R. Hegde, Tara L. Burke, Aaron D. Bossler, Genomic Sequencing Procedure Microcosting Analysis and Health Economic Cost-Impact Analysis: A Report of the Association for Molecular Pathology The Journal of Molecular Diagnostics. ,vol. 18, pp. 319- 328 ,(2016) , 10.1016/J.JMOLDX.2015.11.010

Olivier Harismendy, Megumi Ikeda, Barbara A. Parker, Razelle Kurzrock, Maria Schwaederle, Hatim Husain, Paul T. Fanta, David E. Piccioni, Santosh Kesari, Richard B. Schwab, Sandip P. Patel, Use of Liquid Biopsies in Clinical Oncology: Pilot Experience in 168 Patients. Clinical Cancer Research. ,vol. 22, pp. 5497- 5505 ,(2016) , 10.1158/1078-0432.CCR-16-0318

Jon K C Yoong, Wei Howe Koh, Gim Gee Teng, Manjari Lahiri, Peter P Cheung, Archana R Vasudevan, Li Ching Chew, Bernard Y Thong, Tang Ching Lau, Jane A Clayton, Ee Tzun Koh, Swee Cheng Ng, Keng Hong Leong, Singapore Chapter of Rheumatologists Consensus Statement on the Eligibility for Government Subsidy of Biologic Disease Modifying Antirheumatic Agents for Treatment of Rheumatoid Arthritis (RA). Annals Academy of Medicine Singapore. ,vol. 43, pp. 400- ,(2014)