Comparison of the effects of ranitidine, cimetidine and thioridazine on psychomotor functions in healthy volunteers.

摘要: Eight healthy male volunteers participated in four experimental sessions which they ingested one of the following drugs: ranitidine hydrochloride (150 mg), cimetidine (400 thioridazine (50 placebo (lactose). Drugs were allocated to subjects and a double-blind fashion, according balanced cross-over design. The subjects' mood state psychomotor performance assessed 1 3 h after drug taking. Mood was measured using battery visual analogue scales, pencil-and-paper tests, critical flicker fusion frequency, wire-maze tracing tapping. Ranitidine had no significant effect on subjectively rated alertness, whereas caused decrease alertness. tests (digit cancellation, digit symbol substitution, copying), decrement these tests. tracing, tapping rate. Thioridazine impairment as evidenced by all instrumental It is concluded that, contrast similarly cimetidine, has little alertness volunteers.