Inflammatory myofibroblastic tumor, inflammatory fibrosarcoma, and related lesions: An historical review with differential diagnostic considerations

摘要: The concept of the inflammatory myofibroblastic tumor (IMT) has evolved from an already perplexing pathological process, pseudotumor, which was initially recognized in lung and regarded as a pseudoneoplasm, although its histological features resembled spindle cell sarcoma. Despite findings their apparent prognostic implications, most affected individuals regardless primary site have had favorable clinical outcomes. designation pseudotumor came to be widely accepted, these lesions were clearly tumors or masses that may not been pseudoneoplasms. An aberrant exaggerated response tissue injury without established cause generally favored pathogenesis IMT. Once myofibroblast identified function repair established, this type found variety soft nodular fasciitis malignant fibrous histiocytoma. eventually principal provided opportunity redesignate Some aspects IMT began suggest possibility are more similar neoplasms than postinflammatory process. Another step evolution occurred with report mesenteric retroperitoneal latter but aggressive behavior warrant interpretation malignancy fibrosarcoma. fibrosarcoma appear many overlapping features. These histogenetically related, if they separate entities, differentiated by degrees absolutes. therapeutic approach should relay primarily on surgical resection. Studies future possibly resolve question whether synonomous closely related entities.