HAM/TSP: recent perspectives in Japan.

摘要: Neurologic diseases associated with human T-cell lymphotropic virus type I (HTLV-I) infection have a clinical spectrum that includes myelopathy (HTLV-I-associated myelopathy/tropical spastic paraparesis, HAM/TSP) as the central manifestation. Many signs of involvement outside nervous system (CNS) been described in some patients HAM/TSP and triggered advanced discovery HTLV-I-associated concepts HTLV-I-infected individuals without CNS involvement. Most these exhibit common viroimmunologic characteristics include distributional bias HTLV-I activation between blood flow affected lesions accumulated cellular immune responses lesions. These facts suggest vulnerable tissue(s) may not be defined by an exclusive tissue specificity, but steps HTLV-I-versus-host interactions important role pathologic process(es) diseases. This review summarizes recent perspectives pathogenesis Japan. Furthermore, feasible pathogenic infected cells responding immunocompetent tissues is emphasized.