Impact of PPAR-Alpha Polymorphisms—The Case of Metabolic Disorders and Atherosclerosis

摘要: Peroxisome proliferator activated receptor α (PPARα) has the most relevant biological functions among PPARs. Activation by drugs and dietary components lead to major metabolic changes, from reduced triglyceridemia improvement in syndrome. Polymorphisms of PPARα are interest order improve our understanding disorders associated with a raised or risk diseases. polymorphisms mainly characterized two sequence L162V V227A, latter occurring only Eastern nations, numerous SNPs (Single nucleotide polymorphisms) less clear role. The minor allele associates total cholesterol, LDL-C (low-density lipoprotein cholesterol), triglycerides, HDL-C (high-density metabolism), elevated (a). An increased cardiovascular is not clear, whereas diabetes liver steatosis well supported. V227A polymorphism instead linked reduction γ-glutamyltranspeptidase levels non-drinking Orientals, being drinkers. Lastly, rs4353747 high-altitude appetite loss. These other associations indicate predictive potential for an improved human disease, which also explain variability clinical response specific drug treatments approaches.