Tryptophan Metabolism, Inflammation, and Oxidative Stress in Patients with Neurovascular Disease

摘要: Atherosclerosis is a leading cause of major vascular events, myocardial infarction, and ischemic stroke. Tryptophan (TRP) catabolism was recognized as an important player in inflammation immune response having together with oxidative stress (OS) significant effects on each phase atherosclerosis. The aim the study to analyze relationship plasma levels TRP metabolites, inflammation, OS patients neurovascular diseases (acute stroke (AIS), carotid artery stenosis (SCAS)) healthy controls. Blood samples were collected from 43 (25 SCAS, 18 AIS) 25 concentrations twelve riboflavin, neopterin (NEO, marker inflammation), malondialdehyde (MDA, OS) measured by liquid chromatography–tandem mass spectrometry (LC-MS/MS). Concentrations seven metabolites (TRP, kynurenine (KYN), 3-hydroxykynurenine (3-HK), 3-hydroxyanthranilic acid (3-HAA), anthranilic (AA), melatonin (MEL), tryptamine (TA)), NEO, MDA significantly different studied groups. Significantly lower TRP, KYN, 3-HAA, MEL, TA, higher found AIS compared SCAS patients. concentration both group (p < 0.001, p = 0.004, respectively) controls, NEO enhanced 0.003) AIS. did not directly correlate groups, except for 1) negative correlation 2) activity aminotransferase (r −0.552, 0.018; r −0.504, 0.033, respectively). In summary, metabolism clearly more deregulated patients; effect should be further elucidated.