Lower serum dipeptidyl peptidase IV activity in treatment resistant major depression: Relationships with immune-inflammatory markers

摘要: Previous research in this laboratory has shown that major depression is accompanied by decreased serum activity of dipeptidyl peptidase IV (DPP IV), a serine protease cleaves N terminal dipeptides from peptides with penultimate proline or alanine. DPP involved the metabolism peptides, T cell activation and proliferation, including production cytokines, such as interleukin-1 (IL-1) IL-2. The aim study was to examine (i) treatment resistant (TRD) relation other established immune inflammatory markers illness, (ii) effects antidepressive on activity. Serum significantly lower TRD than normal controls. In depressed subjects, there were significant positive relationships between total protein, albumin, zinc, iron transferrin. group number CD4+T cells CD4+/CD8+ ratio. There no subchronic antidepressants findings suggest that: may occur chronic depression, well acute phase depression; accompanies 'chronic' response (iii) tightly coupled increased CD4+ but not Our results do exclude possible longer-term DPP-IV