DNA of human papillomavirus type 16 in dysplastic and malignant lesions of the conjunctiva and cornea.

摘要: Abstract Human papillomaviruses are receiving attention for their role in the pathogenesis of cancer, especially cancer anogenital tract. Although strains human papillomavirus associated with benign lesions conjunctiva, association conjunctival dysplastic and carcinomas has remained unclear. We examined a group neoplastic conjunctiva presence DNA sequences types 16 18, using vitro gene amplification polymerase chain reaction. Tissue specimens five one invasive carcinoma swab mucosa both corneas patient unilateral corneal dysplasia contained related to type 16. All were positive sequences. Viral was not detected six control from patients melanoma, papilloma, nevus, or pterygium. conclude that papillomav...