Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis

摘要: Urinary tract infections in young, healthy women frequently recur, despite their traditional classification as acute infections. Conventional wisdom dictates that uropathogens causing recurrent such individuals come from the fecal or vaginal flora, same manner initial infection. However, recent studies of uropathogenic Escherichia coli have found it can carry out a complex developmental program within superficial epithelial cells mouse bladder, forming intracellular bacterial communities with many biofilm-like properties. These biofilms allow bacteria to outlast strong host immune response establish dormant reservoir pathogens inside bladder cells. Re-emergence this might be source