The unc-8 and sup-40 genes regulate ion channel function in Caenorhabditis elegans motorneurons.

摘要: Two Caenorhabditis elegans genes, unc-8 and sup-40, have been newly identified, by genetic criteria, as regulating ion channel function in motorneurons. dominant alleles cause motorneuron swelling similar to that of other neuronal types mutants the deg-1 gene family, which is homologous a mammalian family encoding amiloride-sensitive sodium subunits. As for previously identified members, mutations are recessively suppressed mec-6 gene, probably encodes second type component. An unusual mutation, sup-41 (lb125), also co-suppresses deg-1, suggesting existence yet another common component channels containing or Dominant, transacting, intragenic suppressor isolated both consistent with idea that, like their homologues, two products multimers. The sup-40 (lb130) mutation dominantly suppresses produces novel phenotype hypodermal nuclei. may encode an regulator can correct osmotic defect caused abnormal channels.