The control of gastric acid and Helicobacter pylori eradication
作者： G. Sachs , J. M. Shin , K. Munson , O. Vagin , N. Lambrecht
DOI: 10.1046/J.1365-2036.2000.00837.X
关键词:
摘要: This review focuses on the gastric acid pump as a therapeutic target for control of secretion in peptic ulcer and gastro-oesophageal reflux disease. The mechanism proton inhibitors is discussed well their clinical use. biology Helicobacter pylori denizen then discussed, with special regard to its mechanisms resistance. Here properties products urease gene clusters, ureA, B ureI, E, F, G H are explored order explain unique location this pathogen. dominant requirement resistance presence gated urea transporter, UreI, which increases access juice intrabacterial 300-fold. enables rapid continuous buffering bacterial periplasm approximately pH 6.0, allowing growth at acidic 1 mM urea. A hypothesis basis combination therapy eradication also presented.
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