Suppression of tumor growth by a mini-E1A gene

作者: Mien-Chie Hung , Di-Hua Yu , Hua Chen

DOI:

关键词:

摘要: The present invention provides methods and compositions for the suppression of oncogenic transformation, tumorigenesis metastasis. discloses functional domains E1A responsible mini-E1A constructs that can be used tumor suppression. also novel use in combination with chemotherapeutic drugs and/or tyrosine kinase inhibitors.

参考文章(144)
L. Burnett, P. Berg, A. R. Buchman, APPENDIX A The SV40 Nucleotide Sequence Cold Spring Harbor Monograph Archive. pp. 799- 841 ,(1980) , 10.1101/087969141.10B.799
Pamela L. Larsen, Clark Tibbetts, Mutated adenovirus E1A gene for E1A promoter stimulation ,(1988)
T R Flotte, B J Carter, Adeno-associated virus vectors for gene therapy Gene Therapy. ,vol. 2, pp. 357- 362 ,(1995)
S. Karlsson, K. Van Doren, S.G. Schweiger, A.W. Nienhuis, Y. Gluzman, Stable gene transfer and tissue-specific expression of a human globin gene using adenoviral vectors. The EMBO Journal. ,vol. 5, pp. 2377- 2385 ,(1986) , 10.1002/J.1460-2075.1986.TB04507.X
N. Muzyczka, Use of adeno-associated virus as a general transduction vector for mammalian cells. Current Topics in Microbiology and Immunology. ,vol. 158, pp. 97- 129 ,(1992) , 10.1007/978-3-642-75608-5_5
D. Gershenson, M. C. Hung, X. Zhang, E. Silva, Amplification and rearrangement of c-erb B proto-oncogenes in cancer of human female genital tract. Oncogene. ,vol. 4, pp. 985- 989 ,(1989)
Seung-il Shin, [31] Use of nude mice for tumorigenicity testing and mass propagation Methods in Enzymology. ,vol. 58, pp. 370- 379 ,(1979) , 10.1016/S0076-6879(79)58152-X
S.S. Huang, J.S. Huang, Purification and characterization of the neu/erb B2 ligand-growth factor from bovine kidney. Journal of Biological Chemistry. ,vol. 267, pp. 11508- 11512 ,(1992) , 10.1016/S0021-9258(19)49939-0
D L May, T A Walker, J L Cook, D Shalloway, B Holskin, B A Wilson, M J Chen, Role of tumor necrosis factor-alpha in E1A oncogene-induced susceptibility of neoplastic cells to lysis by natural killer cells and activated macrophages. Journal of Immunology. ,vol. 142, pp. 4527- 4534 ,(1989)