Synthesis of N-alkyl-3-sulfonylindoles and N-alkyl-3-sulfanylindoles by cascade annulation of 2-alkynyl-N,N-dialkylanilines.
作者： Jatuporn Meesin , Manat Pohmakotr , Vichai Reutrakul , Darunee Soorukram , Pawaret Leowanawat
DOI: 10.1039/C7OB00366H
关键词:
摘要: An efficient and metal-free approach to N-alkyl-3-sulfonylindoles N-alkyl-3-sulfanylindoles from 2-alkynyl-N,N-dialkylanilines has been developed. In the presence of iodine tert-butylhydroperoxide (TBHP), a variety underwent cascade radical annulation yield 3-arylsulfonylindoles. contrast, 3-arylsulfanylindoles were conveniently prepared by mediated electrophilic reactions. The present protocol uses economical environmentally friendly I2–TBHP or I2 system, potentially bioactive with various functional groups successfully synthesized in moderate good yields.
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