IRR: A Novel Member of the Insulin Receptor Family
作者： Valerie M. Watt , Peter Shier , Joanne Chan , Bradley A. Petrisor , Swarna K. Mathi
DOI: 10.1007/978-1-4615-2988-0_13
关键词:
摘要: Insulin’s effects, including its pivotal regulation of blood glucose levels, are mediated by a cell-surface receptor (reviewed in Olefsky, 1990; Ullrich and Schlessinger, 1990). The structure the insulin receptor, defined using recombinant DNA techniques, exhibits high degree overall similarity with for structurally related insulin-like growth factor (IGF), IGF-I (for review, see Czech, 1989). These heterotetrameric glycoproteins consists extracellular a-subunits containing insulin-binding region disulfide-bonded to β-subunits which span membrane contain cytoplasmic tyrosine kinase activated binding (Ebina et al., 1985; 1986). α-and derived proteolytic cleavage proreceptor.
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