Phenotypic and functional cellular differences between human CD3- decidual and peripheral blood leukocytes.

摘要: CD3- leukocyte clones derived from human decidualized endometrial tissue of first trimester pregnancy have been compared with PBL clones. Most decidual granulated (DGL) were CD16- CD56+, whereas most CD16+ CD56+. DGL and clones, whether or not, showed MHC-nonrestricted NK cell activity. However, had low cytotoxic activity against the NK-resistant line BSM, strongly cytotoxic. Cytolytic has also investigated in respect target HLA-G expression, because this nonpolymorphic class I MHC molecule is expressed selectively by invasive fetal cytotrophoblast. Class HLA Ag loss mutants killed efficiently Expression transfected HLA-B8 increased their sensitivity to lysis expression commonly led decreased killing. In addition, effects uncloned on one-way MLR examined. These cells very poor responders and, unless cultured induce II molecules, stimulators. When fresh DGLs added as third-party cells, either autologous allogeneic responder [3H]TdR incorporation was MLR. Thus, express cytolytic activity, notably HLA-negative but offers protection cells. may function suppress responses.