The conundrum of the high-affinity NGF binding site formation unveiled?

作者: Petr V. Konarev , Alberto Cassetta , Francesca Paoletti , Dmitri I. Svergun , Doriano Lamba

DOI: 10.1016/J.BPJ.2014.11.3485

关键词:

摘要: … of human NGF, we propose that it is the oligomerization state of the secreted NGF that may … In particular, the protein cores of growth hormone and prolactin granules disperse slowly (86…

参考文章(94)
J. K. Angleson, A. J. Cochilla, G. Kilic, I. Nussinovitch, W. J. Betz, Regulation of dense core release from neuroendocrine cells revealed by imaging single exocytic events Nature Neuroscience. ,vol. 2, pp. 440- 446 ,(1999) , 10.1038/8107
W. L. Delano, The PyMOL Molecular Graphics System DeLano Scientific. ,(2002)
A Sutter, R J Riopelle, R M Harris-Warrick, E M Shooter, Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells. Journal of Biological Chemistry. ,vol. 254, pp. 5972- 5982 ,(1979) , 10.1016/S0021-9258(18)50507-X
B L Hempstead, N Patil, B Thiel, M V Chao, Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding Journal of Biological Chemistry. ,vol. 265, pp. 9595- 9598 ,(1990) , 10.1016/S0021-9258(19)38707-1
Kenneth P. Murphy, Ernesto Freire, Thermodynamics of structural stability and cooperative folding behavior in proteins. Advances in Protein Chemistry. ,vol. 43, pp. 313- 361 ,(1992) , 10.1016/S0065-3233(08)60556-2
Ralph A. Bradshaw, Hubert Hondermarck, Nerve growth factor receptors Biomembranes: A Multi-Volume Treatise. ,vol. 6, pp. 177- 196 ,(1997) , 10.1016/S1874-5342(96)80036-5
Christine Brennan, Kimberly Rivas-Plata, Story C. Landis, The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo. Nature Neuroscience. ,vol. 2, pp. 699- 705 ,(1999) , 10.1038/11158