ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)

摘要: Devil Facial Tumour 1 (DFT1) is one of two transmissible neoplasms Tasmanian devils (Sarcophilus harrisii) predominantly affecting their facial regions. DFT1’s cellular origin that Schwann cell lineage where lesions are evident macroscopically late in the disease. Conversely, pre-clinical timeframe from transmission to appearance DFT1 remains uncertain demonstrating importance an effective biomarker. We show ERBB3, a marker expressed normally by developing neural crest and cells, immunohistohemically DFT1, therefore potential ERBB3 as biomarker was explored. Under hypothesis serum levels may increase invades local distant tissues our pilot study determined normal with DFT1. Compared baseline unaffected devils, showed significant elevation levels. Interestingly cutaneous lymphoma (CL) also when compared without Thus, elevated otherwise healthy looking could predict possible or CL captive wild devil populations would have implications on management, welfare survival devils. therapeutic target exists consider modes administration eradicate wild.