Sensory Deviancy Detection Measured Directly Within the Human Nucleus Accumbens

摘要: Rapid changes in the environment evoke a comparison between expectancy and actual outcome to inform optimal subsequent behavior. The nucleus accumbens (NAcc), key interface hippocampus neocortical regions, is candidate region for mediating this comparison. Here, we report event-related potentials obtained from NAcc using direct intracranial recordings 5 human participants while they listened trains of auditory stimuli differing their degree deviation repetitive background stimuli. revealed an early mismatch signal (50-220 ms) response all deviants. activity time window was also sensitive statistics stimulus deviancy, with larger amplitudes as function level deviancy. Importantly, predicted generation longer latency scalp (300-400 ms). results provide evidence that component network engaged encoding sensory environmental.