Early anterior cingulate involvement is seen in presymptomatic MAPT P301L mutation carriers.

摘要: PET imaging of glucose metabolism has revealed presymptomatic abnormalities in genetic FTD but not been explored MAPT P301L mutation carriers. This study aimed to explore the patterns hypometabolism and atrophy Eighteen asymptomatic members from five families with a were recruited study, six carriers, twelve mutation-negative controls. All participants underwent standard behavioural cognitive assessment as well [18F]FDG-PET 3D T1-weighted MRI brain scans. Regional standardised uptake value ratios (SUVR) for scan volumes calculated an automated segmentation obtained compared between carrier control groups. The mean (standard deviation) estimated years symptom onset was 12.5 (3.6) group range 7 18 years. No differences cognition seen groups, all carriers had global CDR plus NACC FTLD 0. Significant reduction [18F] FDG anterior cingulate (mean 1.25 [standard deviation 0.07]) controls (1.36 [0.09]). A similar significant also grey matter volume (0.60% [0.06%]) (0.68% [0.08%]). other regions. Anterior are both apparent presymptomatically cohort Such specific marker may prove be helpful stratification future trials.