Biomimetic approach to tunable adhesion of polyurethane adhesives through Fe3+ crosslinking and hydrophobic tween units with balance of adhesion/cohesion forces

摘要: Abstract Biocompatible adhesives have some limitations such as weak adhesion and low flexibility. To overcome these limitations, we described multiple strategies to provide strong high flexibility through Tweens, chlorogenic acid (CLA) polyethylene glycol (PEG) by reducing excessive interaction between tissue the adhesive. We synthesized polyurethane-based using aliphatic 4,4′-methylenebis(cyclohexyl isocyanate) (HMDI), PEG, CLA Tween units. Hydrophobic side chains in polymer resulted lower Tg (−36.95-30.36 °C) which indicated more The highest strengths were found almost 346 kPa for bare polyurethane 492 kPa chelated (PU-T40-CLA-15% (5% 40, 15% 80% PEG 200 containing polymer)) with FeCl3. addition of units provided stable structure polymers proved vitro erosion studies. Relatively values seen 5.7, 5.6 8.2% PU-T40-CLA-5% (15% 5% polymer), PU-T40-CLA-10% (10% 10% PU-T40-CLA-15% respectively. In biocompatibility results showed cell viability PU-T40-15% than 100%. Overall, our findings that material designs (PU-T-CLAs) significant challenges improving flexible character adhesive strength adhesives.