Brain-derived neurotrophic factor Regulation, effects, and potential clinical relevance
作者： E. E. Benarroch
DOI: 10.1212/WNL.0000000000001507
关键词:
摘要: Brain-derived neurotrophic factor (BDNF) is the most ubiquitous and intensively studied member of family neurotrophins in CNS. The transcriptional regulation BDNF complex involves both epigenetic control transcription factors. produced “on demand” response to neuronal activity from a precursor pro-BDNF that transported processed via secretory pathway. effects mature are mediated by tropomyosin-related kinase B (TrkB, tyrosine B) receptor, which triggers phosphorylation cascades promote protein synthesis, axonal growth, dendritic maturation, use-dependent synaptic plasticity, neuroprotection. In contrast, binds common neurotrophin receptor p75NTR promotes apoptosis. can also be released microglia may bidirectionally affect inhibitory neurotransmission Disturbances control, transport, or signaling contribute variety neurologic psychiatric disorders, including Alzheimer disease (AD), Huntington (HD), spinocerebellar ataxia type 6 (SCA6), neuropathic pain, Rett syndrome, depression, schizophrenia, drug addiction. There several recent reviews on these subjects.1–20
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