p53 Inactivation leads to impaired motor synchronization in mice
作者： Aline L. M. Campana , Laure Rondi-Reig , Christine Tobin , Ann M. Lohof , Florence Picquet
DOI: 10.1046/J.1460-9568.2003.02631.X
关键词:
摘要: We have combined genetic and pharmacological approaches to investigate the behavioural consequences of inactivation murine p53 protein. Our analysis revealed that p53-null mice (p53KO) exhibit a very specific significant motor deficit in rapid walking synchronization. This deficit, observed using rotarod test, was only defect p53KO mice. demonstrated it not due an increase neuronal number or abnormal connectivity olivo-cerebellar system, thought control In order test role central nervous we injected inhibitor activation, pifithrin-a, into cerebellum wild-type treatment mimicked synchronization mice, suggesting presence protein is necessary execute this walking. investigation reveals functional cerebellar adult
sci-hub.se 参考文章(79)
François Conquet, Zafar I. Bashir, Ceri H. Davies, Hervé Daniel, Francesco Ferraguti, Fabio Bordi, Karin Franz-Bacon, Angelo Reggiani, Valerie Matarese, Françoise Condé, Graham L. Collingridge, Francis Crépel, Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1 Nature. ,vol. 372, pp. 237- 243 ,(1994) , 10.1038/372237A0
L Rondi-Reig, N Delhaye-Bouchaud, J Mariani, J Caston, Role of the inferior olivary complex in motor skills and motor learning in the adult rat Neuroscience. ,vol. 77, pp. 955- 963 ,(1997) , 10.1016/S0306-4522(96)00518-0
Hadi Shojaeian Zanjani, Karl Herrup, Jean-Marie Guastavino, Nicole Delhaye-Bouchaud, Jean Mariani, Developmental studies of the inferior olivary nucleus in staggerer mutant mice Developmental Brain Research. ,vol. 82, pp. 18- 28 ,(1994) , 10.1016/0165-3806(94)90144-9
N. Auvray, J. Caston, A. Reber, T. Stelz, Role of the cerebellum in the ontogenesis of the equilibrium behavior in the young rat: a behavioral study. Brain Research. ,vol. 505, pp. 291- 301 ,(1989) , 10.1016/0006-8993(89)91455-8
Stefano Schiaffino, Luisa Gorza, Saverio Sartore, Leopoldo Saggin, Simonetta Ausoni, Monica Vianello, Kristian Gundersen, Terje LØmo, Three myosin heavy chain isoforms in type 2 skeletal muscle fibres Journal of Muscle Research and Cell Motility. ,vol. 10, pp. 197- 205 ,(1989) , 10.1007/BF01739810
Lloyd Guth, Frederick J. Samaha, Qualitative differences between actomyosin ATPase of slow and fast mammalian muscle Experimental Neurology. ,vol. 25, pp. 138- 152 ,(1969) , 10.1016/0014-4886(69)90077-6
Sheila L. Handley, Siddika Mithani, Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of 'fear'-motivated behaviour. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 327, pp. 1- 5 ,(1984) , 10.1007/BF00504983
A Lalouette, A Lohof, C Sotelo, J.-L Guénet, J Mariani, Neurobiological effects of a null mutation depend on genetic context: comparison between two hotfoot alleles of the delta-2 ionotropic glutamate receptor Neuroscience. ,vol. 105, pp. 443- 455 ,(2001) , 10.1016/S0306-4522(01)00193-2
Francis Crepel, Jean Mariani, Nicole Delhaye-Bouchaud, Evidence for a multiple innervation of Purkinje cells by climbing fibers in the immature rat cerebellum. Journal of Neurobiology. ,vol. 7, pp. 567- 578 ,(1976) , 10.1002/NEU.480070609
Kimberly A. Huey, Sue C. Bodine, Changes in myosin mRNA and protein expression in denervated rat soleus and tibialis anterior. FEBS Journal. ,vol. 256, pp. 45- 50 ,(1998) , 10.1046/J.1432-1327.1998.2560045.X