Allergy development and the intestinal microflora during the first year of life

摘要: Background: The intestinal microflora is a likely source for the induction of immune deviation in infancy. Objective: purpose this study was to prospectively relate allergy development 2 countries differing with respect prevalence atopic diseases. Methods: Newborn infants were followed through first years life Estonia (n = 24) and Sweden 20). By that age, 9 Estonian Swedish had developed dermatitis and/or positive skin prick test results. Stool samples obtained at 5 6 days 1, 3, 6, 12 months, 13 groups aerobic anaerobic microorganisms cultivated use standard methods. Results: In comparison healthy infants, babies who less often colonized enterococci during month (72% vs 96%; P < .05) bifidobacteria year (17% 39% 42% 69%; .05). Furthermore, allergic higher counts clostridia 3 months (median value, 10.3 7.2 log10; colonization Staphylococcus aureus also (61% 23%; .05), whereas Bacteroides lower (9.9 10.6 Conclusion: Differences composition gut flora between will not develop are demonstrable before any clinical manifestations atopy. Because observations made different standards living, we believe our findings could indicate role protection from allergy. (J Allergy Clin Immunol 2001;108:516-20.)