Blood Perfusion and Cellular Microstructural Changes Associated With Iron Deposition in Multiple Sclerosis Lesions

摘要: Background and Purpose: Susceptibility-weighted imaging (SWI) has emerged as a useful clinical tool in many neurological diseases including multiple sclerosis (MS). This study aims to investigate the relationship between SWI signal changes due iron deposition MS lesions tissue blood perfusion microstructural abnormalities better understand their underlying histopathologies. Methods: Forty-six patients with relapsing remitting were recruited for this study. Conventional FLAIR, pre- post-contrast T1-weighted imaging, SWI, diffusion tensor (DTI), dynamic susceptibility contrast (DSC) MRI performed these at 3T. The was processed using both magnitude phase information one slice minimal intensity projection (mIP) multiplication factor of 4. classified into 3 types based on lesional appearance mIP relative perilesional normal appearing white matter (peri-NAWM): Type-1: hypointense, Type-2: isointense, Type-3: hyperintense lesions. DTI DSC data offline generate DTI-derived mean diffusivity (MD) fractional anisotropy (FA) maps, well DSC-derived cerebral flow (CBF) volume (CBV) maps. Comparisons measurements peri-NAWM, different lesions, performed. Results: A total 137 identified FLAIR that include 40 Type-1, 46 Type-2, 51 Type-3 according peri-NAWM. All lesion showed significant higher MD lower FA compared peri-NAWM (P < 0.0001). Compared Type-1 (likely represent deposition), Type-2 had significantly 0.001) 0.05), while Type 0.05). 0.0001) marginally Conclusion: differences metrics associated appear may help identify destructive pathways myelin axons evolution related inflammatory activities.