Glucocorticoid-Associated Osteoporosis in Chronic Inflammatory Diseases: Epidemiology, Mechanisms, Diagnosis, and Treatment

摘要: Children with chronic illnesses such as Juvenile Idiopathic Arthritis and Crohn's disease, particularly when taking glucocorticoids, are at significant risk for bone fragility. Furthermore, childhood illness interferes achieving normal peak mass, life-long fracture is increased. Osteopenia osteoporosis, which increasingly recognized in pediatric likely results from numerous disease- treatment-related factors, including glucocorticoid exposure. Diagnosing osteoporosis complicated by the limitations of current noninvasive techniques DXA, despite its remains gold standard. The risk:benefit ratio treatment confounded potential spontaneous restitution mass deficits reshaping previously fractured vertebral bodies. Bisphosphonates have been used to treat secondary children, but limited experience long-term toxicity warrant caution routine use. This article reviews factors that influence loss strength evidence effective treatments, particular patients gastrointestinal rheumatologic disorders who receiving therapy.