Ontogenesis of a biological clock for serotonin:acetyl coenzyme A N-acetyltransferase in pineal gland of rat.

摘要: Abstract Serotonin:acetyl coenzyme A N-acetyltransferase (EC 2.3.1.5) Activity in pineal gland was assayed rats which were born and raised under diurnal lighting conditions, continuous darkness, or constant light. N-Acetyltransferase activity the pups showed a rhythmic pattern, with high enzyme during dark period. The darkness also phase of delayed by 8 hr 7-week-old pups; began evening 12-day-old regularly 1 every week. illumination pattern; 3 When mother coupled maintained pregnancy after born, their again pattern. These observations indicate that biological clock for is generated independently environmental lighting. mothers reversed conditions transferred into light, pattern inverted 180 degrees from mothers. similar to It suggested absence light-darkness cycle, rat sets rhythm synchronize her own rhythm. reared foster different original mother, closer suggesting plays predominant role setting pups.