Assessment of the key regulatory genes and their Interologs for Turner Syndrome employing network approach.

摘要: Turner Syndrome (TS) is a condition where several genes are affected but the molecular mechanism remains unknown. Identifying that regulate TS network one of main challenges in understanding its aetiology. Here, we studied regulatory from manually curated reported literature and identified essential proteins involved TS. The power-law distribution analysis showed carries scale-free hierarchical fractal attributes. This organization maintained self-ruled constitution nodes at various levels without having centrality–lethality control systems. Out twenty-seven culminating into leading hubs network, two key regulators (KRs) i.e. KDM6A BDNF. These KRs serve as backbone for all activities. Removal does not cause breakdown, rather change topological properties was observed. Since evolutionarily conserved, orthologs selected interacting C. elegans, cat macaque monkey (lower to higher level organisms) were identified. We deciphered three important interologs KDM6A-WDR5, KDM6A-ASH2L WDR5-ASH2L form triangular motif. In conclusion, these expected signifying their biological importance.