Ecofriendly syntheses of phenothiazones and related structures facilitated by laccase – a comparative study

摘要: Abstract The biocatalytic synthesis of phenothiazones and related compounds has been achieved in an aqueous system under mild conditions facilitated by laccase oxidation. It was found that coupling 2-aminothiophenol directly with 1,4-quinones, the product yields could be significantly increased compared to generating 1,4-quinones situ from corresponding hydroquinones via However, still proved pivotal for achieving highest catalyzing final oxidation step. Furthermore, a difference reactivity aromatic aliphatic amines toward 1,4-naphthoquinone is observed. This study provides sustainable approach biologically important class compounds.