Reliability and validity of the gastrointestinal symptom rating scale in patients with gastroesophageal reflux disease

摘要: The objective of this study was to evaluate the reliability and validity Gastrointestinal Symptom Rating Scale (GSRS) in US patients with gastroesophageal reflux disease (GERD). Five hundred sixteen adults predominant heartburn symptoms GERD were recruited from gastroenterologist family physician practices treated 6 weeks 150mg ranitidine twice daily identify poorly responsive symptomatic GERD. GSRS, Medical Outcomes Study Short Form-36 (SF-36) Health Survey Psychological General Well-being (PGWB) scale administered at baseline after treatment. Reported ratings GERD-related patient diaries measured. GSRS contains five scales: syndrome, abdominal pain, constipation diarrhoea syndrome indigestion syndrome. internal consistency reliabilities for scales ranged 0.61 0.83 intraclass correlation coefficients 0.42 0.60. scores correlated SF-36 PGWB number severity symptoms. Patients two or three clinician-rated reported worse compared fewer (p < 0.0001). Statistically significant differences mean observed between treatment responders non-responders 0.0001) showing a response had larger changes their than not standardized means 1.43 scores. It concluded that is brief, fairly comprehensive assessment common gastrointestinal has good construct discriminate by symptom are useful patient-rated evaluating outcomes