The Randomized Clinical Trial of Pentoxifylline for Reduction of Blood Pressure in Patients with Primary Hypertension

摘要: Background: Pentoxifylline (PTX) is a xanthine derivative with the potential cardiovascular effects. This study was done to evaluate impact of pentoxifylline on blood pressure when added patients’ antihypertensive regimen. Methods: A randomized control trial were carried out 100 patients primary hypertension for three-month period. The intervention group received 1200 mg daily PTX in three divided doses plus standard treatment medications, whereas only hypertension. Patients’ measured at baseline, 4, and 12 weeks after intervention. Patients also followed up major adverse cardiac events. Results: After 4 study, no significant difference observed systolic (SBP) (135 ± 16 vs. 136.2 17.2 mmHg, p=.72; 134.8 13.3 134.3 14.7 p=.85) diastolic (DBP) (81.5 9.9 82.4 12.9 p=.69; 80.8 9 80.4 10.7 p=.84) between two groups. Conclusion: result showed that has not effect BP