Identification of new allergenic constituents and proof of evidence for coniferyl benzoate in Balsam of Peru

摘要: Background: Balsam of Peru is used worldwide for different purposes. Three quarters its constituents are still unknown, and main allergens have not been identified to date. Objective: Chemical examination balsam experimental sensitization was performed identify the sensitizers. Methods: Using analytic methods such as thin-layer chromatography, high-pressure liquid gas chromatography/mass spectrometry, experiments in guinea pigs resulted identification a greater number determination their sensitizing potency. Results: Benzyl isoferulate, coniferyl cinnamate, hydroconiferyl benzoate were among others new constituents. Also, presence could be shown first time. It showed strongest capacity all compounds tested followed by benzyl isoferulate. The latter significant cross-linking allergen because it occurs propolis well. Conclusion: New Peru. Based on these results, patch test series has created that recommended epicutaneous tests Peru-positive patients.