Impact of conjugate 7-valent vaccination in Belgium: addressing methodological challenges.
作者： Germaine Hanquet , Tinne Lernout , Anne Vergison , Jan Verhaegen , Esther Kissling
DOI: 10.1016/J.VACCINE.2011.02.016
关键词:
摘要: In Belgium, the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into national schedule in 2007. The early impact of PCV7 vaccination on paediatric invasive disease estimated by comparing pre- and post-vaccination incidence from surveillance. children <2 year-olds, vaccine-serotype declined 96% but non-vaccine-types increased 2-3-fold. Overall decreased 23-46%, depending adjustment for under-reporting pre-vaccine trends. Non-vaccine-types 1 19A had before use, suggesting contribution other factors. Estimation data should adjust trends, serotype dynamics need further exploration. © 2011 Elsevier Ltd.
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