Perinatal Immunity to Group B β-Hemolytic Streptococcus Type Ia

摘要: Sera from 14 of 56 adult women protected mice intraperitoneal challenge with mouse-virulent group B Streptococcus serotype Ia, and sera seven 25 nonparturient in this were bactericidal for greater than 99% the organisms presence normal polymorphonuclear leukocytes. There no discrepancies between vivo vitro assays. Protective activity was found IgG class sera, IgM one. Opsonic partially dependent on heat-labile serum factors. Of 31 mother-cord pairs studied, maternal protective, but four corresponding cord not. Pooled human gamma-globulin injected by either or intramuscular route bacterial challenge.