A partial hepatectomy results in altered expression of clock-related and cyclic glyceraldehyde 3-phosphate dehydrogenase (GAPDH) genes.
作者： Takuya Iwasaki , Ken-ichi Nakahama , Mamoru Nagano , Atsuko Fujioka , Harumasa Ohyanagi
DOI: 10.1016/J.LFS.2003.11.010
关键词:
摘要: The liver is among the peripheral organs that display a clear circadian rhythmicity. To investigate whether specific pathological conditions affect rhythms in liver, we examined expression profiles of clock-related and glyceraldehyde 3-phosphate dehydrogenase (GADPH) genes following partial hepatectomy mouse. This surgical procedure causes dynamic proliferation residual hepatocytes within one day operation hepatectomized mice demonstrated higher both mPer1 mPer2 remaining tissue when compared to control had undergone Sham-operation. In contrast, mCry1 gene displayed profile was similar group. addition, GAPDH levels, no oscillations Sham-hepatectomized mice, underwent daily alterations hepatectomy. These findings suggest regenerative state affects not only but also are constitutively expressed under steady conditions.
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