Nachweis von Antiphospholipidantikörpern

作者: P. Quehenberger , I. Pabinger-Fasching

DOI: 10.1007/978-3-642-01544-1_70

关键词:

摘要: Antiphospholipidantikorper sind eine heterogene Gruppe von Antikorpern, die gegen Komplexe bestehend aus Phospholipiden und einem phospholipidbindenden Protein gerichtet sind. Die haufigsten Proteine β2-Glykoprotein I Prothrombin. Ein quantitativer Nachweis Antiphospholipidantikorpern ist mit ELISA-Verfahren moglich, gereinigte Phospholipid-Protein-Komplexe als Antigene einsetzen. Eine Untergruppe durch Eigenschaft gekennzeichnet, phospholipidabhangige Gerinnungszeiten zu verlangern. Diese werden Lupusantikoagulanzien bezeichnet konnen nur Gerinnungstests nachgewiesen werden, Phospholipide limitierende Grose In der Routine “diluted Russell’s viper venom time„ “upussensitive aktivierte partielle Thromboplastinzeit„ am eingesetzt.

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