Cephalosporin-induced biliary sludge in children

摘要: Background. One of the side effects third generation cephalosporins is formation cephalosporin-induced biliary pseudolithiasis (CIBPL). The purpose study was to establish peculiarities sludge during application in treatment acute respiratory infections children. Materials and methods. We examined 46 children aged 2 15 years with infections. Сephalosporins were administered intravenously age doses. evaluated biochemical blood test echosonography (ultrasound) tract before after end antibiotic therapy all Results. According ultrasound data, 10 patients (21.7 %) infections, a course cephalosporins, heterogeneous contents detected gallbladder lumen form hyperechoic suspension, which indicated CIBPL. average CIBPL 9.05 ± 1.44 within range 4 years. found that 60 % children, proceeded subclinically. results serum showed CIBPL, an increase activity alanine aminotransferase, aspartate alkaline phosphatase observed. It 22.9 against background ceftriaxone therapy, 9 — ceftazidime. Biliary formed 54.5 receiving high doses (100 mg/kg/day), 75 cases days using this antibiotic. Conclusions. obtained 21.7 had A particularly risk developing observed when prolonged cephalosporins.