Substantial risk of recurrence even after 5 recurrence-free years in early-stage hepatocellular carcinoma patients

摘要: Background/aims Although hepatocellular carcinoma (HCC) is notorious for its high recurrence rate, some patients do not experience more than 5 years after resection or radiofrequency ablation early-stage HCC. For those with five recurrence-free period, the risk of HCC within next remains unknown. Methods A total 1,451 consecutive (median, 55 old; males, 79.0%; hepatitis B virus-related, 79.3%) good liver function (Child-Pugh class A) diagnosed by Barcelona Clinic Liver Cancer Staging and received as an initial treatment between 2005 2010 were analyzed. Results During a median follow-up period 8.1 years, 961 (66.2%) experienced recurrence. The cumulative rates increased to 39.7%, 60.3%, 71.0% at 2, 5, 10 respectively, did reach plateau. Five diagnosis, 487 alive without experiencing Among them, during 3.9 additional (range, 0.1-9.0 years), 127 (26.1%) 5-year rate (5-10 from diagnosis) was 27.0%. Male sex, higher fibrosis-4 scores, alpha-fetoprotein levels associated later among who years. Conclusion following high, indicating that warrant continued surveillance, even