Isolation and Characterization of Neural Progenitor Cells From Bone Marrow in Cell Replacement Therapy of Brain Injury.

摘要: Many studies supported that bone marrow mesenchymal stem cells (BM-MSCs) can differentiate into neural cells, but few researchers detected mature and function of nerve especially in vivo study. Some even suggested BM-MSCs transplantation would not be able to functional cells. To figure out the dispute, this study examined marrow-derived sphere-like harvested via cell suspension culture, then identified as progenitor (BM-NPCs) by finding expression genes proteins, characteristic differentiation induced through both methods. Moreover, BM-NPCs showed long-term survival improved ethological histological indexes brain injury rats, demonstrating nervous differentiated from BM-NPCs. These vitro results confirmed differentiating This provided valuable experimental data for BM-NPCs, suggesting a potential alternative treatment central disease.